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Target intelligence / Profile preview
Folate Transporter (N/A)
- Target
- N/A
- Molecular classification
- Transporter, Membrane Protein, Receptor
01
Overview
Folate transporters are membrane proteins responsible for the cellular uptake and systemic distribution of folates, essential B vitamins involved in DNA synthesis, repair, and methylation. The major types include the Reduced Folate Carrier (RFC/SLC19A1), the Proton-Coupled Folate Transporter (PCFT/SLC46A1), and Folate Receptors (FOLR1-4). These transporters play critical roles in maintaining folate homeostasis and are implicated in various diseases, including hereditary folate malabsorption and cancer. They also mediate the uptake of antifolate drugs like methotrexate.
- Other names
- Reduced Folate Carrier (RFC)SLC19A1Proton-Coupled Folate Transporter (PCFT)SLC46A1Folate Receptor Alpha (FRα)FOLR1Folate Receptor Beta (FRβ)Folate Receptor Gamma (FRγ)Folate Receptor Delta (FRδ)FOLR2FOLR3FOLR4
02
Mechanism of action
Mediates cellular uptake of folates and antifolates via various mechanisms including antiport, proton-coupled transport, and endocytosis.
03
Biological functions
Folate transportVitamin B9 transportCellular uptakeSystemic distributionDNA synthesisDNA repairMethylationEndocytosis
04
Disease associations
Hereditary Folate MalabsorptionCancerCerebral Folate DeficiencyNeurodevelopmental Disorders
05
Safety considerations
Drug resistance (e.g., to methotrexate)Targeting specificity in cancer therapyPotential for off-target effects
06
Interacting drugs
Methotrexate
1 more in the full profile.
07
Biomarkers
FOLR1 expression in tumorsSLC46A1 mutations in HFM
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