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Target intelligence / Profile preview
Protozoan Mitochondrial Respiratory Chain (Eimeria species) (ETC (Eimeria))
- Target
- ETC (Eimeria)
- Molecular classification
- Enzyme complex, Oxidoreductase, Electron transport chain component
01
Overview
The mitochondrial respiratory chain in Eimeria species is a critical pathway for ATP production via oxidative phosphorylation. It comprises several enzyme complexes (I-IV) and mobile electron carriers that facilitate electron transfer from substrates to oxygen. Unique features, like alternative electron acceptors (fumarate) and usage of menaquinones, distinguish it from the host's respiratory chain, making it a promising target for antiparasitic drugs.
- Other names
- Eimeria Mitochondrial Respiratory ChainApicomplexan Electron Transport ChainEimeria ETC
02
Mechanism of action
Inhibition of electron transport, disruption of proton gradient, and blockage of ATP synthesis
03
Biological functions
Oxidative phosphorylationATP synthesisElectron transportEnergy production
04
Disease associations
CoccidiosisParasitic infection
05
Safety considerations
Potential for off-target effects on host mitochondrial functionDevelopment of drug resistance in parasites
06
Interacting drugs
Cyanide
2 more in the full profile.
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