Pseudogene similar to part of excision repair cross-complementing rodent repair deficiency, complementation group 3

This gene (ENSG00000226750) is annotated as a **pseudogene** that has sequence similarity to part of the ERCC3 gene ("excision repair cross-complementing rodent repair deficiency, complementation group 3"), also known as XPB. Unlike the functional ERCC3 gene, which encodes a DNA helicase essential for nucleotide excision repair and regulation of transcription, this pseudogene does not encode a functional protein and is not considered a therapeutic target[5][6]. Pseudogenes may arise from gene duplication or retrotransposition events but lack coding potential and are generally not involved in disease or drug interaction. There is no evidence of a functional role, disease mechanism, or utility as a therapeutic target for ENSG00000226750. **Summary:** ENSG00000226750 is a pseudogene, not a protein-coding gene or functional receptor/enzyme/target. Information on canonical ERCC3 is not directly applicable to this entry, and it should not be considered a drug target or biomarker[5][6].