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Fetal pulmonary artery smooth muscle cell
- Molecular classification
- Other (cell type; not a molecular target)
01
Overview
Fetal pulmonary artery smooth muscle cells are specialized muscle cells found in the walls of pulmonary arteries during fetal development. They are integral to regulating blood flow by contracting and relaxing and also play a role in developmental vascular remodeling. In disease conditions such as pulmonary hypertension, these cells can undergo abnormal proliferation and contribute to pathological thickening of the vessel wall. Fetal PASMCs are distinguishable by the high expression of ACTA2 and display molecular diversity early in lung development. They are not, however, a "target" in the traditional molecular sense, but rather a cell population of interest for developmental biology and vascular disease research[2][3][5].
- Other names
- Pulmonary artery smooth muscle cell (PASMC)fetal PASMCfetal pulmonary arterial smooth muscle cell
02
Biological functions
Regulation of vascular tone (contracting and relaxing to control blood flow)Cell proliferation and differentiation during developmentContribution to pulmonary vascular remodelingResponse to hypoxia
03
Disease associations
Pulmonary arterial hypertensionPulmonary vascular remodeling and related cardiovascular disease
04
Safety considerations
None specific, but dysregulation can be involved in vascular diseases
05
Biomarkers
ACTA2 (alpha-smooth muscle actin, marks smooth muscle lineage)Unique marker sets distinguishing airway and vascular SMCs (e.g. NTRK3, MEF2C for vascular SMCs; HHIP, MYLK, IGF1 for airway SMCs)
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