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Target intelligence / Profile preview
Purine Nucleoside Phosphorylase (E. coli) (PNP)
- Target
- PNP
- Molecular classification
- Enzyme, Glycosyltransferase, Family I purine nucleoside phosphorylase
01
Overview
Purine nucleoside phosphorylase (PNP) from *Escherichia coli* is an enzyme that catalyzes the reversible phosphorolysis of purine nucleosides and 2′-deoxypurine nucleosides, resulting in the formation of a free purine base and ribose 1-phosphate or deoxyribose 1-phosphate. This reaction is essential for the salvage pathway of purines, allowing cells to recycle purines for nucleotide synthesis.
- Other names
- E. coli PNPPurine nucleoside phosphorylasePNP-II (xapA)Pyrimidine/purine nucleoside phosphorylase (ppnP)
02
Mechanism of action
Catalyzes the reversible phosphorolysis of purine nucleosides and 2′-deoxypurine nucleosides
03
Biological functions
Nucleotide metabolismPurine salvage pathwayPhosphorolysis of purine nucleosidesRibose 1-phosphate formationDeoxyribose 1-phosphate formation
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