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Target intelligence / Profile preview
Purinergic P2X7 Receptor (Non-Functional Form) (nfP2X7)
- Target
- nfP2X7
- Molecular classification
- Ligand-gated ion channel, P2X receptor, Receptor
01
Overview
The purinergic P2X7 receptor (P2X7R) is an ATP-gated ion channel. The non-functional form, abbreviated as nfP2X7, refers to a conformation or variant of the receptor that does not exhibit typical pore-forming activity in response to ATP stimulation. It is commonly found on cancer cells and may contribute to tumor survival. Antibodies have been developed that specifically recognize epitopes unique to the non-functional conformation allowing discrimination between functional and non-functional forms for research or therapeutic purposes.
- Other names
- Non-functional P2X7RnfP2X7 receptor
02
Mechanism of action
Antibody-based therapies targeting the unique conformational epitope of nfP2X7
03
Biological functions
Altered ion channel activityPotential immune evasionCancer cell survival
04
Disease associations
Cancer
05
Safety considerations
Off-target effects of antibodiesPotential immune-related adverse events
06
Biomarkers
nfP2X7 expression levels in tumor cells
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