PYM homolog 1, exon junction complex associated factor (PYM1)

PYM homolog 1, exon junction complex associated factor (PYM1) is a protein-coding gene that encodes a key regulator of the exon junction complex (EJC), a multiprotein assembly deposited upstream of exon-exon junctions of mRNA during splicing[1][2][5]. PYM1 acts in EJC disassembly, particularly through a translation-independent mechanism, helping to ensure the proper removal and recycling of EJCs after mRNA processing and during translation[2][3]. The protein interacts directly with both the MAGOH/RBM8A heterodimer of the EJC and small ribosomal subunit, and has been shown to modulate mRNA fate, influencing processes such as nonsense-mediated decay (NMD) and translation efficiency[2][4][5]. PYM1 is sometimes hijacked by certain viruses (e.g., flaviviruses) to alter host mRNA regulation[2]. The gene is primarily classified in the exon junction complex associated factor family and does not act as a classical receptor, enzyme, transporter, or primary therapeutic target. There are no established drugs targeting PYM1, and its alterations are not currently used as clinical biomarkers or linked to prominent safety concerns[1][2][5].

Other names

WIBGPartner of Y14 and MagoPYMPYM homolog 1protein wibg homologwithin bgcn homologPYM1