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Pyridoxal phosphate phosphatase (PHOSPHO2) (PHOSPHO2)
- Target
- PHOSPHO2
- Molecular classification
- Enzyme, Phosphatase, pyridoxal phosphate phosphatase
01
Overview
Pyridoxal phosphate phosphatase (PHOSPHO2) is an enzyme that hydrolyzes pyridoxal 5'-phosphate (PLP), the bioactive coenzyme form of vitamin B6, into pyridoxal, thus regulating the intracellular concentration of PLP. PLP is a vital cofactor required for more than 100 enzymatic reactions involved in amino acid metabolism, neurotransmitter synthesis, and cellular signaling. PHOSPHO2’s function is essential for vitamin B6 homeostasis, ensuring neither excess nor deficiency of PLP, and allowing proper cellular metabolism. While PHOSPHO2 has not been directly linked to specific disease states, altered PLP regulation can be relevant to metabolic or neurological conditions. PHOSPHO2 is classified within the broader family of phosphatases and is conserved across species.
- Other names
- Phosphatase, orphan 2MGC22679pyridoxal phosphate phosphatase PHOSPHO2
02
Biological functions
Regulation of intracellular pyridoxal phosphate (PLP) homeostasisCatalytic dephosphorylation of PLP (the active form of vitamin B6)Modulation of vitamin B6 metabolism
03
Disease associations
Other. No known direct implication in major diseases, but potential indirect roles in pathologies related to vitamin B6 homeostasis or rare metabolic disorders
04
Safety considerations
No notable safety concerns reported; though theoretical, dysregulation of PLP metabolism could impact vitamin B6 levels and related enzymatic processes
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