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Target intelligence / Profile preview
RAB, member RAS oncogene family-like 6 (RABL6)
- Target
- RABL6
- Molecular classification
- Small GTPase, Ras superfamily, Rab-like protein
01
Overview
RAB, member RAS oncogene family-like 6 (RABL6) is a member of the Ras superfamily of small GTPases. The protein binds both GTP and GDP and is implicated in regulating cell growth, proliferation, and survival. Overexpression of RABL6 has been observed in breast cancer, suggesting a possible oncogenic role. Multiple transcript variants and isoforms of this gene exist. While its precise cellular functions remain an active area of research, the protein may modulate cell cycle progression and interact with numerous proteins associated with membrane trafficking and cellular signaling.
- Other names
- RABL6C9orf86
02
Mechanism of action
Not established for pharmacologic agents; hypothetical mechanisms may include inhibition of cell proliferation or alteration of GTPase activity, inferred from its Ras-like functions
03
Biological functions
GTP bindingRegulation of cell growth and proliferationPotential involvement in cell survival
04
Disease associations
Cancer (notably breast cancer)Potential implication in Angelman Syndrome (unclear functional role)
05
Safety considerations
No specific safety concerns highlighted in search resultsGeneral concerns could include unintended effects on cell growth or proliferation if targeted due to its potential tumor suppressor and cell cycle regulatory roles
06
Biomarkers
None established for patient selection or efficacy monitoringOverexpression may be linked to certain cancers (especially breast cancer)
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