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Radiolabeled Vitamin B12 (Cobalt-58, Cobalt-57, or Cobalt-60) (N/A)
- Target
- N/A
- Molecular classification
- Vitamin, Radiopharmaceutical, Diagnostic agent
01
Overview
Radiolabeled vitamin B12 (typically with Cobalt-58, Cobalt-57, or Cobalt-60) is used as a diagnostic tracer to assess vitamin B12 absorption in the gastrointestinal tract. By measuring the amount of radioactivity absorbed or excreted, clinicians can diagnose conditions like pernicious anemia and other malabsorption disorders.
- Other names
- ^58Co-vitamin B12^57Co-vitamin B12^60Co-vitamin B12Cobalt-58 labeled cobalaminCobalt-57 labeled cobalaminCobalt-60 labeled cobalamin
02
Mechanism of action
Acts as a tracer, following the natural absorption pathway of vitamin B12 to enable quantification of intestinal uptake.
03
Biological functions
Tracing vitamin B12 absorptionQuantifying intestinal uptakeDiagnostic imaging
04
Disease associations
Diagnosis of pernicious anemiaDiagnosis of vitamin B12 malabsorption syndromesDiagnosis of intestinal disorders affecting B12 absorption
05
Safety considerations
Exposure to radiation (low doses)Requires handling according to radiation safety protocolsPotential for allergic reactions (rare, but possible)Contraindicated in pregnancy without careful risk-benefit assessment
06
Biomarkers
Vitamin B12 absorption rateRadioactivity levels in blood/plasmaUrinary excretion of radiolabeled B12Fecal excretion of radiolabeled B12Whole-body retention of radiolabeled B12
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