Radixin messenger RNA 3' untranslated region (RDX mRNA 3' UTR)

Radixin (RDX) is a scaffold protein belonging to the Ezrin-Radixin-Moesin (ERM) family, playing a pivotal role in linking the actin cytoskeleton to the plasma membrane (UniProt P35241). The 3' untranslated region (UTR) of the RDX mRNA serves as a primary regulatory hub, containing multiple seed sequences for microRNAs, such as the miR-196 family, that modulate its expression levels (PubMed: 25672304). In many human cancers, including gastric and hepatocellular carcinomas, the loss of microRNA-mediated suppression leads to RDX overexpression, which facilitates tumor cell invasion, epithelial-mesenchymal transition (EMT), and metastasis (PubMed: 23463688). Targeting the RDX mRNA 3' UTR using antisense oligonucleotides (ASOs) or microRNA mimics represents a strategic approach to downregulate RDX expression at the post-transcriptional level. This therapeutic strategy aims to disrupt the structural and signaling functions of Radixin, thereby inhibiting the metastatic potential of aggressive tumors. Additionally, Radixin is essential for the proper localization of transporters in the liver, meaning that therapeutic modulation must account for potential impacts on bile salt secretion (PubMed: 11448994).

Other names

Radixin 3' UTRRDX 3' untranslated regionRDX 3'-UTRRadixin mRNA 3' UTR

MicroRNA-mediated gene silencing and antisense-mediated inhibition of translation or induction of mRNA degradation.