Ras association domain family member 1 isoform A mRNA 3'-untranslated region (RASSF1A mRNA 3'-UTR) (RASSF1A mRNA 3'-UTR)

The Ras association domain family member 1 isoform A (RASSF1A) mRNA 3'-untranslated region (3'-UTR) is a critical regulatory segment of the RASSF1A transcript, which encodes a potent tumor suppressor protein involved in cell cycle arrest, microtubule stabilization, and apoptosis (Source: UniProt Q9NS23). This 3'-UTR serves as a docking site for various microRNAs (miRNAs), such as miR-193a-3p, miR-602, and miR-543, which negatively regulate RASSF1A expression by inducing mRNA degradation or translational repression (Source: PubMed PMID: 26464702, 23564476). In many human cancers, including hepatocellular carcinoma and lung cancer, the overexpression of these targeting miRNAs leads to the functional loss of RASSF1A, contributing to uncontrolled cell proliferation and metastasis. Consequently, the RASSF1A 3'-UTR is an emerging therapeutic target for RNA-based interventions, such as antagomirs or antisense oligonucleotides, designed to prevent miRNA binding and restore tumor suppressor levels. Research into this target focuses on reversing the post-transcriptional silencing of RASSF1A to inhibit oncogenic signaling and sensitize cells to chemotherapy. While currently in the preclinical stage, targeting this region represents a novel approach to precision oncology.

Other names

RASSF1A 3'-UTRRas association domain-containing protein 1 isoform A 3'-UTRRASSF1 3'-UTRRASSF1A 3' untranslated region

MicroRNA-mediated post-transcriptional gene silencing and antisense-mediated inhibition of microRNA binding to restore protein expression.