Ras Protein (Mutant) (Ras (Mutant))

Mutant Ras proteins are constitutively active GTPases that drive uncontrolled cell proliferation and survival, playing a critical role in cancer development. Common oncogenic mutations occur at positions 12, 13, and 61, impairing GTPase activity and locking Ras in its active GTP-bound state. Therapeutic strategies aim to inhibit Ras signaling by targeting post-translational modifications, directly binding mutant Ras, or inhibiting downstream effector pathways. The three main isoforms are HRAS, NRAS and KRAS (with splice variants 4A and 4B).

Other names

Mutant Ras GTPaseOncogenic RasKRAS (Mutant)HRAS (Mutant)NRAS (Mutant)

Inhibition of Ras signaling by targeting post-translational modifications (farnesylation), direct binding to mutant Ras (e.g., KRAS G12C), or inhibiting downstream effectors (e.g., RAF, MEK, PI3K)