RB binding protein 4, chromatin remodeling factor (RBBP4)

RB binding protein 4, chromatin remodeling factor (RBBP4), is a ubiquitously expressed nuclear protein belonging to the WD-repeat protein family. It is a core histone-binding subunit that participates in multiple chromatin-associated complexes, such as the Mi-2/NuRD, CAF-1, SIN3A, and PRC2 complexes. RBBP4 is involved in targeting chromatin assembly factors, chromatin remodeling factors, and histone deacetylases to nucleosomal DNA, thereby regulating histone acetylation status, gene expression, and transcriptional repression. It binds to both histone H3 and H4 tails and plays a crucial role in cell cycle regulation, development, and maintenance of genome stability. Disruption of RBBP4 affects processes such as cell proliferation, apoptosis, and epigenetic regulation and is implicated in cancer, premature aging syndromes, and memory loss associated with aging

Other names

Retinoblastoma-binding protein 4RbAp48NURF55Lin-53Nucleosome-remodeling factor subunit RBAP48Chromatin assembly factor 1 subunit CChromatin assembly factor I p48 subunitRetinoblastoma-binding protein p48CAF-1 subunit CCAF-I 48 kDa subunitCAF-I p48MSI1 protein homolog

Inhibition of associated HDAC complexes leads to increased histone acetylation and transcriptional derepression Drugs modulating associated regulatory pathways (e.g., cAMP/PKA pathway in memory studies) may alter RBBP4-related function