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Target intelligence / Profile preview
Recepteur d'Origine Nantais protein (RON)
- Target
- RON
- Molecular classification
- Receptor, Receptor Tyrosine Kinase (RTK)
01
Overview
RON (Recepteur d'Origine Nantais), also known as MST1R or Macrophage Stimulating 1 Receptor, is a receptor tyrosine kinase belonging to the MET family. It is activated by its ligand, Macrophage Stimulating Protein (MSP), leading to autophosphorylation and activation of downstream signaling pathways such as PI3K/AKT, MAPK/ERK, and PLCγ/PKC. These pathways regulate various cellular processes, including cell survival, migration, proliferation, and invasion. RON is implicated in tumor progression and metastasis, making it a potential therapeutic target in cancer.
- Other names
- MST1RMacrophage Stimulating 1 Receptor
02
Mechanism of action
Inhibition of RON kinase activity or downstream signaling pathways.
03
Biological functions
Cell survivalCell migrationCell proliferationCell differentiationCell adhesionCell invasionCell motilityApoptosisWound healingInnate immune responseMacrophage activity modulationSignal transduction
04
Disease associations
CancerTumor progressionMetastasis
05
Safety considerations
Potential for off-target effects due to homology with other RTKs.Development of resistance to RON inhibitors.
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