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Recepteur d'origine nantais proto-oncogene tyrosine-protein kinase (RON)
- Target
- RON
- Molecular classification
- Receptor, Receptor Tyrosine Kinase, MET proto-oncogene family
01
Overview
RON (Recepteur d'origine nantais) is a receptor tyrosine kinase belonging to the MET proto-oncogene family. It is activated by Macrophage-Stimulating Protein (MSP) and plays a role in cell migration, invasion, inflammation, and embryonic development. Aberrant overexpression or activation of RON is implicated in various cancers, making it a target for anti-cancer drug development.
- Other names
- MST1Rmacrophage stimulating 1 receptorRON receptormacrophage-stimulating protein receptor
02
Mechanism of action
Inhibition of tyrosine kinase activity; Antibody-mediated cytotoxicity
03
Biological functions
Signal transductionCell migrationCell invasionEmbryonic developmentTissue repairRegulation of inflammationCell proliferation
04
Disease associations
CancerInflammation
05
Safety considerations
Limited clinical benefit of monoclonal antibodiesPotential for off-target effects with kinase inhibitorsDysregulation leading to chronic inflammatory disease progression
06
Interacting drugs
Monoclonal antibodies targeting RON
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