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Target intelligence / Profile preview
Recepteur d'Origine Nantais protein tyrosine kinase (RON)
- Target
- RON
- Molecular classification
- Receptor Tyrosine Kinase, RTK, c-MET subfamily
01
Overview
Recepteur d'Origine Nantais (RON) protein tyrosine kinase, also known as MST1R, is a receptor tyrosine kinase (RTK) with significant roles in cell signaling, cancer progression, and metastasis. It regulates inflammation, cell growth, migration, epithelial-to-mesenchymal transition (EMT), tissue repair, and immune responses. RON is synthesized as a single-chain precursor, which is cleaved into an extracellular α-chain and a transmembrane β-chain containing the intracellular tyrosine kinase domain. Binding of Macrophage-stimulating protein (MSP) to RON leads to receptor dimerization and autophosphorylation on key tyrosines in the cytoplasmic domain, activating downstream pathways such as MAPK/ERK and PI3K/AKT. RON overexpression/activation drives oncogenic processes, making it a target for anti-cancer therapies.
- Other names
- MST1RMacrophage-stimulating protein receptor
02
Mechanism of action
Small molecule inhibitors targeting RON activity or monoclonal antibodies targeting ligand interaction
03
Biological functions
Cell growthCell migrationEpithelial-to-mesenchymal transition (EMT)Tissue repairImmune responseInflammation regulationCell survival
04
Disease associations
CancerTumorigenesisMetastasisGastric cancerBreast cancerColon cancerLung cancer
05
Safety considerations
Aberrant or constitutive activation correlates with aggressive cancer phenotypesHigh expression often correlates with metastatic disease progression
06
Biomarkers
RON overexpressionRON activation
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