Respiratory Syncytial Virus fusion glycoprotein; Respiratory Syncytial Virus attachment glycoprotein (RSV F protein; RSV G protein)

Respiratory Syncytial Virus surface proteins include the fusion glycoprotein (F), which drives fusion of the viral and host cell membranes, the attachment glycoprotein (G), which binds to host cell receptors such as CX3CR1 to initiate infection and modulate immunity, and the small hydrophobic protein (SH), which may function as a viroporin (ion channel) affecting membrane permeability. The F protein is the primary target for antiviral drugs and vaccines, and both F and G are important targets for neutralizing antibody responses. These proteins are fundamental to viral entry and pathogenesis, and are central to current RSV prophylactic and therapeutic strategies[1][2][3][4][5][6][7].

Other names

RSV F proteinRSV fusion proteinRSV G proteinRSV attachment proteinRSV SH proteinRSV small hydrophobic protein

Neutralizing antibody binding to F and/or G protein, blocking entry or fusion; Inhibition of fusion activity or attachment by small molecules/peptides