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Target intelligence / Profile preview
Respiratory Syncytial Virus Fusion Glycoprotein (Prefusion Conformation) (RSV F protein (prefusion))
- Target
- RSV F protein (prefusion)
- Molecular classification
- Viral envelope protein, Fusion protein, Glycoprotein
01
Overview
The fusion (F) glycoprotein of respiratory syncytial virus (RSV) is a type I viral fusion protein located on the surface of the virion. It plays a critical role in mediating the fusion of the viral envelope with host cell membranes, enabling viral entry and infection. The prefusion conformation is metastable and represents the form present before membrane fusion occurs. The prefusion conformation exposes unique antigenic sites not present or less accessible in postfusion form, which are the target of potent neutralizing antibodies.
- Other names
- RSV Fusion Protein (Prefusion)RSV F glycoprotein (prefusion)Prefusion F proteinPrefusion RSV F
02
Mechanism of action
Target of neutralizing antibodies; vaccines designed to elicit antibodies that block fusion.
03
Biological functions
Membrane fusionViral entryReceptor binding
04
Disease associations
InfectionRespiratory disease
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