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Target intelligence / Profile preview
Respiratory Syncytial Virus Fusion Glycoprotein F (Pre-fusion Conformation) (RSV F (pre-F))
- Target
- RSV F (pre-F)
- Molecular classification
- Viral Fusion Protein, Glycoprotein, Class I Fusion Protein
01
Overview
The respiratory syncytial virus (RSV) fusion glycoprotein F is a class I viral fusion protein essential for RSV entry into host cells. It mediates the fusion of the viral envelope with the host cell membrane, allowing viral RNA to enter and initiate infection. The F protein exists in two major conformations: prefusion (pre-F) and postfusion (post-F). The prefusion conformation is present on the surface of infectious virions before membrane fusion occurs and is highly immunogenic. Stabilized versions of pre-F are leading candidates for next-generation RSV vaccines due to their ability to elicit strong neutralizing responses.
- Other names
- Pre-fusion RSV F proteinRSV fusion protein (pre-fusion)RSV F protein (pre-F)Pre-F
02
Mechanism of action
Antibody neutralization of viral fusion; Vaccine-induced antibody response targeting pre-fusion conformation.
03
Biological functions
Virus-cell membrane fusionViral entryReceptor bindingImmunogenicity
04
Disease associations
InfectionRespiratory Syncytial Virus InfectionBronchiolitisPneumonia
05
Safety considerations
Instability of pre-fusion conformationPotential for off-target effects with antibody-based therapiesRisk of enhanced respiratory disease with suboptimal vaccine strategies (historical)
06
Interacting drugs
D25 antibody
5 more in the full profile.
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