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Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (PDE6G)
- Target
- PDE6G
- Molecular classification
- Enzyme, Phosphodiesterase (regulatory subunit)
01
Overview
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (PDE6G) is a regulatory subunit of the rod-specific cyclic GMP phosphodiesterase complex in photoreceptor cells. It is essential for the transmission and amplification of the visual signal in rod cells. The gamma subunit modulates the activity of the alpha and beta catalytic subunits within this phosphodiesterase complex and regulates hydrolysis of cGMP, a key step in phototransduction. Mutations in PDE6G are implicated in inherited retinal diseases such as retinitis pigmentosa[1][2][3][4][6].
- Other names
- PDEGRP57GMP-PDE gammarod cG-PDE Gretinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaphosphodiesterase 6G, cGMP-specific, rod, gamma
02
Biological functions
Signal transductionVisual phototransductionRegulation of cGMP metabolism
03
Disease associations
Retinal degenerative diseaseRetinitis pigmentosa
04
Safety considerations
Potential impact on vision if inhibited or mutated
05
Biomarkers
Mutations associated with retinitis pigmentosa
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