Retinoblastoma binding protein 7, chromatin remodeling factor (RBBP7)

Retinoblastoma binding protein 7 (RBBP7) is a ubiquitously expressed nuclear protein that belongs to the WD-repeat family, serving as a core component of multiple chromatin remodeling complexes. It is central to the regulation of chromatin assembly and histone modification, participating in complexes such as mSin3 co-repressor and nucleosome-remodeling factor (NURF). RBBP7 interacts directly with the tumor suppressor retinoblastoma protein (Rb), influencing cell proliferation, differentiation, and possibly tumorigenesis. The protein also has demonstrated interactions with BRCA1, indicating a potential role in DNA repair and cancer biology. RBBP7 is highly conserved and contributes to nuclear architecture and gene expression regulation via its epigenetic functions.

Other names

RB binding protein 7RBBP7RbAp46Histone-binding protein RBBP7

Indirect inhibition of complexes containing RBBP7, most commonly via histone deacetylase (HDAC) inhibition, resulting in altered transcriptional activity and cell cycle regulation.