Retinoblastoma-like protein 1 mRNA 3' untranslated region (RBL1 mRNA 3'UTR)

The Retinoblastoma-like protein 1 (RBL1) mRNA 3' untranslated region (3'UTR) is a critical regulatory segment of the messenger RNA that encodes the p107 protein. This region serves as a platform for post-transcriptional regulation, containing various motifs and binding sites for microRNAs and RNA-binding proteins that dictate the transcript's stability and translation efficiency (PubMed: 22564877). As a member of the retinoblastoma (Rb) family of pocket proteins, p107 functions as a tumor suppressor by binding to and inhibiting E2F transcription factors, thereby controlling the G1 to S phase transition of the cell cycle (UniProt: P28749). Dysregulation of the RBL1 3'UTR, often through the overexpression of oncogenic microRNAs such as miR-223 or miR-107, leads to the downregulation of p107 and promotes uncontrolled cell proliferation in various malignancies (PubMed: 21835910). In the context of drug development, this 3'UTR is considered a target for RNA-based therapeutics, including microRNA mimics and antisense oligonucleotides designed to restore or modulate p107 expression levels. Targeting this region offers a potential strategy to re-establish cell cycle checkpoints in cancer cells, although therapeutic success depends on overcoming challenges related to off-target effects and efficient delivery to target tissues.

Other names

p107 mRNA 3'UTRRetinoblastoma-like 1 3'UTRPRB1 mRNA 3'UTRRetinoblastoma-like protein 1 3'UTRp107 3'UTR

Modulation of p107 protein expression through sequence-specific binding to the 3'UTR, leading to either mRNA degradation or translational inhibition via the RNA-induced silencing complex (RISC).