Retinoic acid receptor (RAR) and Retinoid X receptor (RXR) (RAR, RXR)

The retinoid-dependent intracellular signaling pathway refers to a set of mechanisms in which retinoids (oxidized derivatives of vitamin A, such as all-trans retinoic acid) bind to nuclear receptors called retinoic acid receptor (RAR) and retinoid X receptor (RXR). Upon ligand binding, these receptors form heterodimers, translocate to the nucleus, and bind to specific DNA sequences called retinoic acid response elements (RAREs). This leads to the activation or repression of target genes controlling cellular differentiation, proliferation, and organogenesis. Non-canonical retinoid signaling can also involve rapid kinase-mediated signaling cascades and intercellular communication. Defects or manipulations of these receptors are implicated in a variety of diseases, especially developmental disorders and cancer[1][2][3][4][5][6][7].

Other names

Retinoic acid receptorRARRetinoid X receptorRXRNuclear retinoid receptorRA receptorRexinoid receptor

Agonism of RAR or RXR to induce or repress gene transcription by binding to retinoic acid response elements (RARE) in DNA[2][3][4][5][7] Modulation of cell differentiation and proliferation via altered transcriptional programs