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Retinoic acid receptors (RARs) and retinoid X receptors (RXRs) (RAR/RXR)
- Target
- RAR/RXR
- Molecular classification
- Nuclear receptor, Transcription factor
01
Overview
Retinoic acid receptors (RARs) and retinoid X receptors (RXRs) are a family of nuclear receptors that act as ligand-dependent transcription factors. They regulate gene expression in response to retinoids, such as retinoic acid (tretinoin) and other vitamin A derivatives. RARs and RXRs form heterodimers that bind to specific DNA sequences called retinoic acid response elements (RAREs) to control the transcription of target genes involved in cell growth, differentiation, and apoptosis.
- Other names
- Retinoic acid receptorRARRetinoid X receptorRXR
02
Mechanism of action
Agonist of retinoic acid receptors (RARs) and/or retinoid X receptors (RXRs), leading to altered gene transcription.
03
Biological functions
Gene expression regulationCell differentiationCell proliferationApoptosisImmune responseSignal transduction
04
Disease associations
Acne vulgarisPhotoagingAcute promyelocytic leukemia (APL)Skin cancerOther CancersInflammation
05
Safety considerations
TeratogenicitySkin irritationHypervitaminosis A-like syndromeDrug interactions
06
Interacting drugs
Tretinoin
3 more in the full profile.
07
Biomarkers
PML-RARA fusion protein (for APL)RAR expression levelsRXR expression levels
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