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Reverse Transcriptase (Non-Nucleoside Site) (None)
- Target
- None
- Molecular classification
- Enzyme, Reverse Transcriptase
01
Overview
The non-nucleoside site on HIV-1 reverse transcriptase is a specific allosteric, hydrophobic pocket targeted by non-nucleoside reverse transcriptase inhibitors (NNRTIs). NNRTIs bind to this site and induce conformational changes that disrupt the polymerase activity of reverse transcriptase, inhibiting viral DNA synthesis. This site is unique to HIV-1 RT, making NNRTIs selective for HIV-1. NNRTIs do not inhibit human cellular polymerases.
- Other names
- NNRTI Binding SiteNon-nucleoside siteNNRTI pocket
02
Mechanism of action
Noncompetitive inhibition via allosteric modulation of reverse transcriptase
03
Biological functions
RNA-dependent DNA polymerase activityRibonuclease H activityDNA-dependent DNA polymerase activityReverse transcription
04
Disease associations
Infection
05
Safety considerations
Drug resistance mutationsOff-target effects
06
Interacting drugs
Nevirapine
4 more in the full profile.
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