Target intelligence / Profile preview

Reverse transcriptase (RNA-directed DNA polymerase) (RT)

Target: RT
Molecular classification: Enzyme, Transferase, DNA polymerase

Overview

Other names: RNA-directed DNA polymeraseRNA-dependent DNA polymeraseRetroviral reverse transcriptaseRevertaseRNA-dependent DNA nucleotidyltransferase

Mechanism of action

Nucleoside/Nucleotide Reverse Transcriptase Inhibitors (NRTIs) act as competitive inhibitors that incorporate into viral DNA and cause premature chain termination; Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) bind to an allosteric site near the active center}

Biological functions

Viral replicationReverse transcriptioncDNA synthesisRNA degradation (via RNase H activity)

Disease associations

Infection (HIV/AIDS)Infection (Hepatitis B)Infection (HTLV-1)

Interacting drugs

Zidovudine

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