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Ribonuclease H Recruitment (Cleavage of Target mRNA) (None)

Target: None
Molecular classification: Enzyme, Ribonuclease

Overview

RNase H recruitment refers to the process by which RNase H enzymes are directed to cleave target mRNA molecules. This is typically achieved through the formation of RNA-DNA hybrids, most commonly via antisense oligonucleotides (ASOs) that are complementary to a specific sequence in the target mRNA. When an ASO binds its target, it forms a DNA:RNA duplex that is recognized and cleaved by RNase H, resulting in degradation of the RNA strand and subsequent reduction or elimination of gene expression.

Mechanism of action

Recruitment of endogenous RNase H to cleave target mRNA via RNA-DNA hybrid formation induced by antisense oligonucleotides

Biological functions

Genome maintenanceRNA degradationRemoval of aberrant nucleic acid structures

Disease associations

CancerInfection

Safety considerations

Off-target effects due to ASO designPotential for unintended RNA degradation

Interacting drugs

Antisense oligonucleotides (ASOs)

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