Ribonucleotide reductase regulatory TP53 inducible subunit M2B (RRM2B) (RRM2B)

Ribonucleotide reductase regulatory TP53 inducible subunit M2B (RRM2B), also known as p53R2, is a critical enzyme subunit involved in the production of deoxyribonucleotides (dNTPs) required for DNA synthesis and repair (UniProt Q9NZD9). Unlike the cell cycle-regulated RRM2 subunit, RRM2B is induced by the p53 tumor suppressor in response to DNA damage and is essential for maintaining mitochondrial DNA integrity and supporting DNA repair in non-proliferating cells (PMID: 10821268). Mutations in the RRM2B gene are linked to severe mitochondrial DNA depletion syndromes and other neuromuscular disorders, highlighting its vital role in cellular homeostasis (PMID: 17332321). In oncology, RRM2B is often overexpressed in various cancers, contributing to chemoresistance and tumor progression, making it a significant therapeutic target (NCBI Gene 50484). Drugs targeting RRM2B, such as hydroxyurea and novel small-molecule inhibitors like COH29, aim to disrupt dNTP pools, thereby inhibiting cancer cell proliferation and enhancing the efficacy of DNA-damaging agents (PMID: 24510945).

Other names

p53R2Ribonucleotide reductase M2 subunit beta 2p53-inducible ribonucleotide reductase small subunit 2-like proteinMTDPS8AMTDPS8B

Inhibition of the tyrosyl radical or iron chelation within the small subunit of ribonucleotide reductase, preventing the conversion of ribonucleotides to deoxyribonucleotides (PMID: 10821268).