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Target intelligence / Profile preview
Ribosyldihydronicotinamide dehydrogenase (quinone) (NQO2)
- Target
- NQO2
- Molecular classification
- Enzyme, Oxidoreductase, Flavoprotein
01
Overview
Ribosyldihydronicotinamide dehydrogenase (NQO2) is a cytosolic flavoprotein enzyme that catalyzes the two-electron reduction of quinones to hydroquinones using reduced dihydronicotinamide riboside (NRH) as an electron donor. Unlike its paralog NQO1, it cannot efficiently use NADH or NADPH as reducing cofactors. It plays a role in detoxification pathways and may participate in redox signaling. Its exact physiological function remains under investigation.
- Other names
- Quinone reductase 2QR2NRH:quinone oxidoreductase 2NMOR2
02
Mechanism of action
Two-electron reduction of quinones using NRH as electron donor. Off-target interaction with various drugs.
03
Biological functions
DetoxificationQuinone reductionRedox homeostasisPossible role in redox signaling
04
Disease associations
Oxidative stress-related diseases
05
Safety considerations
Off-target drug interactionsPotential for generating reactive oxygen species
06
Interacting drugs
Resveratrol
3 more in the full profile.
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