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Target intelligence / Profile preview
Ring finger protein, transmembrane 1 (RNFT1)
- Target
- RNFT1
- Molecular classification
- Enzyme, RING finger protein family, Transmembrane protein, ERAD pathway component, Ubiquitin-binding protein
01
Overview
Ring finger protein, transmembrane 1 (RNFT1) is a membrane-anchored E3 ubiquitin-protein ligase acting in the ERAD pathway, protecting cells from ER stress and apoptosis, with potential relevance to protein misfolding diseases.
- Other names
- E3 ubiquitin-protein ligase RNFT1PTD016RING finger and transmembrane domain-containing protein 1Protein PTD016
02
Mechanism of action
Ubiquitin ligase inhibition or modulation would alter substrate ubiquitination and ERAD activity, impacting cell viability under ER stress. Specific drug mechanisms not reported.
03
Biological functions
Endoplasmic reticulum-associated degradationCellular quality controlRegulation of apoptosisProtein autoubiquitinationUbiquitin signaling
04
Disease associations
Apoptosis and cell deathChromosome 17q23.1-q23.2 deletion syndromeAnkyloglossia with or without tooth anomalies
05
Safety considerations
Inhibition or dysfunction of RNFT1 may impair protein quality control, enhance ER stress, and promote cell death
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