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RNA, 5S ribosomal pseudogene 123 (RNA5SP123) is a human gene classified as a **pseudogene** for 5S ribosomal RNA[8]. Pseudogenes are generally non-functional sequences that arise from gene duplication or retrotransposition and lack the ability to encode active functional products[6][8]. While protein-coding and functional ribosomal RNA genes are essential for ribosome assembly and protein synthesis, pseudogenes such as RNA5SP123 do not produce functional 5S rRNA and do not participate directly in ribosome structure or function[1][3][8]. There is growing interest in pseudogene expression in cancer biology, as pseudogenes can serve as indicators of molecular subtypes or may exert regulatory effects in rare cases; however, there is no evidence that RNA5SP123 is itself implicated as a therapeutic target, marker, or functional element in disease[2][8]. It is included in gene annotation databases such as NCBI as part of the catalog of ribosomal RNA pseudogenes but is not suited for drug discovery or clinical intervention[8].
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