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RNA, 5S ribosomal pseudogene 134 (RNA5SP134)

Target: RNA5SP134
Molecular classification: Pseudogene, Non-coding RNA (pseudogene-derived), Other

Overview

RNA, 5S ribosomal pseudogene 134 (RNA5SP134) is classified as a pseudogene that closely resembles the functional 5S ribosomal RNA gene but lacks protein-coding capability due to mutations or sequence differences[2][4].\nPseudogenes like RNA5SP134 arise from duplication or retrotransposition and generally do not produce functional RNAs or proteins. While the parental gene (5S rRNA) plays an essential structural role in ribosomes by bridging functional centers within the ribosome and facilitating translation[1][3][5], the RNA5SP134 pseudogene itself is considered nonfunctional and is not a direct therapeutic target. In a broader context, some pseudogenes can exert regulatory effects (e.g., via acting as miRNA sponges or modulating expression of related genes)[4], but there is no specific evidence that RNA5SP134 fulfills such roles. Thus, it is mainly of interest for genomic annotation and evolutionary studies rather than as a functional or druggable target.

Other names: RN5S134RNA5SP134RNA, 5S ribosomal 134

Biological functions

Does not encode a functional RNA or protein (nonfunctional by definition as a pseudogene)[2][4]May play regulatory roles at the RNA level, such as miRNA decoy or modulating stability/expression of related functional RNA genes in rare cases[4]

Disease associations

Other (to date, no direct disease linkage established for RNA5SP134; some pseudogenes can regulate disease-critical genes, but not specifically shown for this one)[4]

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