RNA, 5S ribosomal pseudogene 157 (RNA5SP157)

RNA, 5S ribosomal pseudogene 157 (RNA5SP157) is a human *processed pseudogene* derived from the 5S ribosomal RNA gene, belonging to the class of rRNA pseudogenes[4]. Pseudogenes are genetic elements that resemble functional genes but have lost their ability to encode functional products due to accumulation of mutations, lack of regulatory sequences, or integration into genomic contexts that prevent expression[2]. Processed pseudogenes result from the reverse transcription of RNA (typically mRNA or rRNA), producing intron-less DNA copies inserted back into the genome; they commonly lack promoters and are usually not transcribed, nor do they have functional roles as their originating genes do[2]. The parent 5S rRNA is a small, essential component of the large ribosomal subunit playing a structural and connectivity role in ribosomes[1][3][5], but pseudogenes such as RNA5SP157 do not participate in these functions. Most pseudogenes—including rRNA pseudogenes—are not considered functional targets for therapeutic intervention, nor do they serve as drug targets, biomarkers, or sources of disease association. In summary: RNA, 5S ribosomal pseudogene 157 is a non-functional, non-coding human processed pseudogene derived from 5S ribosomal RNA, with no specific molecular function, disease association, or relevance as a pharmacological target.

Other names

RN5S157RNA, 5S ribosomal 157RNA5SP157