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RNA, 5S ribosomal pseudogene 165 (RNA5SP165) is a human pseudogene corresponding to a non-functional copy of the 5S ribosomal RNA gene. Pseudogenes such as RNA5SP165 are typically non-coding and do not produce functional RNA molecules; they arise from gene duplication or retrotransposition events and usually lack the ability to code for functional ribosomal RNA. While ribosomal RNA genes are essential components of the ribosome, which is critical for protein synthesis, pseudogenes like RNA5SP165 are generally not transcribed or do not contribute to ribosome function[2][4][8]. Some recent research has suggested general roles for pseudogene expression as potential biomarkers or regulatory elements in cancer, but no direct interaction, therapeutic targeting, or functional mechanism has been described for RNA5SP165 specifically[6]. This entry is considered incorrect as a therapeutic target: it is not a functional protein, enzyme, receptor, transporter, or relevant RNA for pharmacological intervention. It is instead a non-coding, non-functional genomic element[2][4][8].
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