RNA, 5S ribosomal pseudogene 170 (RNA5SP170)

RNA, 5S ribosomal pseudogene 170 (RNA5SP170) is annotated in human and other genomes as a processed pseudogene homologous to the 5S ribosomal RNA gene[2][4]. Pseudogenes like RNA5SP170 are derived from functional genes but have lost the capacity to encode functional products due to accumulated mutations or genomic rearrangements[2][8]. The parental gene, 5S ribosomal RNA (5S rRNA), encodes a highly conserved RNA component crucial for ribosome assembly and function[1][3][5]. In contrast, the pseudogene RNA5SP170 does not encode a functional RNA or protein, does not participate in ribosomal function, and is not considered a drug target, receptor, enzyme, transporter, or other canonical therapeutic target class[2][4]. Pseudogenes in general may have regulatory roles at the RNA level (e.g., acting as decoys for microRNAs, generating small interfering RNAs, or affecting gene expression through chromatin modifications), but there is no specific evidence for functional or disease relevance of RNA5SP170[8]. As such, RNA5SP170 is usually omitted from lists of actionable or druggable targets and is not involved in pharmacology or human disease monitoring. The "pseudogene" gene type is non-functional by definition[2][4]. There are no known drugs, mechanisms of action, or biomarker roles for RNA5SP170. No safety concerns or therapeutic challenges are associated since it is not a clinical target. Its classification as a "pseudogene" distinguishes it from functional 5S ribosomal RNA genes, which are critical to ribosome structure and protein synthesis but not direct therapeutic targets[1][3]. The presence of "pseudogene" in the name and official annotations signifies that it should not be considered a drug target or functional receptor/enzyme under typical biomedical taxonomy—marking this entry as potentially incorrect in target lists when searching for actionable drug targets[2][4].

Other names

RN5S170RNA, 5S ribosomal 170RNA5SP170