RNA, 5S ribosomal pseudogene 171 (RNA5SP171)

RNA, 5S ribosomal pseudogene 171 (RNA5SP171) is a processed pseudogene belonging to the family of non-coding RNAs derived from the 5S ribosomal RNA gene[2][4][5]. As a pseudogene, RNA5SP171 is not translated into protein, but can be transcribed into RNA. Pseudogenes typically arise through retrotransposition, lack functional activity, and are broadly present throughout the genome[2][4][10]. While 5S rRNA is an integral component of the large ribosomal subunit and is crucial for ribosomal structure and function in protein synthesis[1][3][9], the pseudogene variant (RNA5SP171) does not encode functional ribosomal RNA and does not participate directly in ribosome biogenesis or cellular signaling. Recent research has shown an association between elevated RNA5SP transcripts and interferon signaling in specific pathological states, such as alcohol-associated hepatitis, suggesting a possible secondary role in immune regulation or inflammation, but these findings are limited and not sufficient to define RNA5SP171 as a disease target or biomarker[6]. In summary, RNA, 5S ribosomal pseudogene 171 is best classified as a non-coding RNA pseudogene, not a therapeutic or canonical biological target, with limited evidence for any direct biological or pathological role.

Other names

RN5S171RNA, 5S ribosomal 171RNA5SP171

None (no established mechanism for drug action against this pseudogene)