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RNA, 5S ribosomal pseudogene 238 (RNA5SP238) is a human pseudogene related to the 5S ribosomal RNA gene[1][2][4]. Pseudogenes are genetic elements that resemble functional genes but have lost their protein-coding or RNA-coding capacity due to mutations or loss of regulatory elements. The 5S ribosomal RNA itself is a structural component of the large ribosomal subunit and is essential for ribosome function in protein synthesis; however, RNA5SP238 is classified as a non-coding pseudogene and does not encode a functional RNA product[1][2][5]. Most pseudogenes, including RNA5SP238, have no direct, well-established role in normal physiology or as therapeutic drug targets, though the expression of some pseudogenes can contribute to gene regulatory networks or serve as disease biomarkers in specific contexts such as cancer[6]. There are no known drugs directly interacting with or targeting this pseudogene[1][4][6].
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