Target intelligence / Profile preview

RNA, 5S ribosomal pseudogene 307 (RNA5SP307)

Target
RNA5SP307
Molecular classification
Pseudogene, Non-coding RNA derivative, Other
01

Overview

RNA, 5S ribosomal pseudogene 307 is a processed pseudogene derived from the 5S ribosomal RNA gene. 5S ribosomal RNA itself is a small, highly conserved RNA component of the large ribosomal subunit, essential for ribosome structure and function, but pseudogenes such as RNA5SP307 do not produce functional ribosomal RNAs[1][2]. Processed pseudogenes generally arise through the integration of reverse-transcribed RNA into the genome, lack introns, and are usually transcriptionally inactive due to regulatory mutations[2]. While some pseudogenes have been reported to act as competitive endogenous RNAs or miRNA sponges, modulating gene regulatory networks, there is no evidence that RNA5SP307 fulfills any protein-coding or major regulatory function. Pseudogene expression profiles may have relevance in cancer classification and as molecular markers, but specific clinical roles for RNA5SP307 are not established[4].

Other names
RN5S307RNA5SP307RNA, 5S ribosomal 307
02

Biological functions

Competes for microRNAs (miRNA sponge/competitive endogenous RNA mechanism in some pseudogenes)Potentially involved in gene regulation having sequence similarity to parental ribosomal 5S RNA[2]Other
03

Disease associations

Other; some pseudogenes implicated as regulatory molecules or biomarkers in cancer and disease, but no reported direct role for RNA5SP307[4]Pseudogene expression is sometimes altered in tumors and may serve as molecular markers[4]
04

Biomarkers

Pseudogene expression profiles have potential as molecular biomarkers for cancer stratification[4]None known specifically for RNA5SP307.

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