RNA, 5S ribosomal pseudogene 345 (RNA5SP345)

RNA, 5S ribosomal pseudogene 345 (abbreviated as RNA5SP345) is a **pseudogene** derived from the 5S ribosomal RNA (rRNA) gene family in the human genome[1][8]. Pseudogenes are genomic DNA sequences similar to normal genes but nonfunctional; they may arise from gene duplication or retrotransposition events and acquire disabling mutations[2]. As an rRNA pseudogene, RNA5SP345 does not encode a functional RNA or protein and does not have a known biological function, enzymatic activity, or therapeutic target role. It is primarily classified as a non-coding, nonfunctional sequence with no known involvement in receptor, enzyme, transporter, or signaling processes. While there is evidence that **pseudogene expression in aggregate** may have significance in cancer and other diseases, such effects are not specific to an individual pseudogene like RNA5SP345 and may be mediated through indirect mechanisms, such as acting as competing endogenous RNAs (ceRNAs) for microRNAs[6]. RNA5SP345 itself has no documented disease association, no known drug interactions, and is not considered a therapeutic target. Its primary interest is for genomic annotation and understanding non-coding DNA elements, not for drug discovery or clinical targeting[1][8].

Other names

RN5S345RNA, 5S ribosomal 345RNA5SP345