RNA, 5S ribosomal pseudogene 36 (RNA5SP36)

RNA, 5S ribosomal pseudogene 36 (RNA5SP36) is a non-coding RNA pseudogene, annotated in the human genome as a member of the large family of 5S ribosomal RNA (rRNA) pseudogenes[2]. 5S rRNA itself is a highly conserved small RNA (around 120 nucleotides) that forms an integral part of the large ribosomal subunit and is essential for normal ribosome structure and function[1][3][4]. However, RNA5SP36 does not encode a functional product; instead, it is regarded as a pseudogene—a genomic DNA sequence similar to the normal gene but generally non-functional and not translated into an active RNA biotype or protein[2]. Pseudogenes like RNA5SP36 arise during evolution through gene duplication or retrotransposition but typically accumulate disabling mutations and are not involved in canonical ribosomal synthesis or biogenesis[2]. Unlike their parent 5S rRNA genes, which participate in core ribosome assembly and protein synthesis, pseudogenes generally lack clear biological function and are not established as drug targets, disease markers, or relevant in therapeutic contexts[1][2][4][6]. Occasionally, some 5S rRNA pseudogenes have been implicated in immune sensing as viral infection sensors, but RNA5SP36 itself has not been specifically implicated in such functions; most research focuses on other family members (such as RNA5SP141)[6]. Key distinctions: - RNA5SP36 is neither a receptor, enzyme, transporter, nor a transcription factor. - It is not a drug, disease, or therapeutic target. - It is not known to be a biomarker or to have a role in human disease[2]. - No drugs are known to interact with this pseudogene, nor are there known mechanisms of action, clinical safety concerns, or patient monitoring strategies associated with it[2]. - It is primarily a genomic artifact arising from the duplication of the 5S rRNA gene cluster[2][4]. Summary: RNA, 5S ribosomal pseudogene 36 (RNA5SP36) is a non-functional 5S ribosomal RNA pseudogene present in the human genome, not a protein-coding gene or therapeutic target, with no known biological function, disease involvement, or clinical relevance[2].

Other names

RN5S36RNA, 5S ribosomal 36RNA5SP36