RNA, 5S ribosomal pseudogene 366 (RNA5SP366)

RNA, 5S ribosomal pseudogene 366 (RNA5SP366) is classified as a *pseudogene*, more specifically, an rRNA pseudogene derived from the 5S ribosomal RNA gene family[5][4]. In the human genome, many pseudogenes correspond to ribosomal RNA genes, including those for 5S rRNA. Unlike the canonical 5S rRNA gene that encodes a functional 120 nucleotide non-coding RNA component of the large ribosomal subunit critical for ribosome structure and function[1][3], pseudogenes such as RNA5SP366 are considered non-functional genomic elements. They arise from duplications or retrotranspositions, frequently acquiring mutations that prevent further transcription or function. Pseudogenes may be unprocessed, processed, or unitary, though processed pseudogenes (formed via reverse transcription and reintegration) are common for ribosomal genes[2][4]. RNA5SP366 is **not a functional therapeutic target** or receptor, nor is it known to encode a regulatory transcript with clinical or biomedical relevance[5]. There is no evidence of interaction with drugs, disease association, or use as a biomarker. Its annotation as a pseudogene means it is essentially a genomic relic without known physiological or pathological action. The parental gene family (5S rRNA) is highly conserved, essential for ribosome assembly, and central to protein synthesis[1][3]; the pseudogene, however, does not retain this functionality. **Summary of issues:** - The term RNA5SP366 refers to a *pseudogene*, not a functional receptor, enzyme, or pharmacologically relevant target. - There is **no evidence of druggability, physiological activity, or clinical application** for this locus. - Its naming follows standard pseudogene annotation, rather than a conventional molecular target scheme[5][4].

Other names

RN5S366RNA, 5S ribosomal 366RNA5SP366

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