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Target intelligence / Profile preview
RNA, 5S ribosomal pseudogene 375 (RNA5SP375)
- Target
- RNA5SP375
- Molecular classification
- Other (Pseudogene, specifically an rRNA pseudogene), rRNA pseudogene, Non-coding RNA pseudogene
01
Overview
RNA, 5S ribosomal pseudogene 375 (RNA5SP375) is a non-coding, non-functional genetic sequence classified as a pseudogene within the human genome, derived from the 5S ribosomal RNA gene family[2][6]. Unlike the canonical 5S ribosomal RNA, which is a critical structural component of ribosomes and engages in protein synthesis[1][3][5], RNA5SP375 has lost coding ability and is not transcribed into a functional RNA product. Pseudogenes such as RNA5SP375 typically arise through duplication or retrotransposition events, followed by genetic changes (mutations, truncations, or early stop codons) rendering the sequence inactive and non-essential, with no demonstrated biological or disease role[4][6]. While functional 5S rRNA is highly conserved and plays a pivotal part in ribosome assembly and cellular translation, the pseudogene variant is retained as non-functional genomic DNA and serves as a genetic relic. RNA5SP375 is cataloged in genomic databases with aliases such as RN5S375, but should not be confused with any druggable or disease-relevant target[2][6].
- Other names
- RN5S375RNA, 5S ribosomal 375RNA5SP375
02
Mechanism of action
None
03
Biological functions
None specific—pseudogenes are non-functional; functional 5S rRNA genes are involved in ribosome structure and protein synthesis, but pseudogenes do not participate in these processes
04
Disease associations
None established; pseudogenes generally lack biological activity and direct disease involvement, though some pseudogenes elsewhere in the genome may have regulatory rolesNo specific disease associations documented for RNA5SP375.
05
Safety considerations
None—no safety or therapeutic issues associated with this pseudogene
06
Interacting drugs
None—no drugs interact with this pseudogene
07
Biomarkers
None—no known biomarker utility
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