RNA, 5S ribosomal pseudogene 45 (RNA5SP45)

RNA, 5S ribosomal pseudogene 45 (RNA5SP45) is a processed pseudogene representing a non-functional copy of the 5S ribosomal RNA gene family. While functional 5S rRNA encodes a highly conserved, noncoding RNA that forms part of the large ribosomal subunit in eukaryotes and prokaryotes[1][5], pseudogenes such as RNA5SP45 are generally not transcribed into functional RNA and lack biological activity. Pseudogenes can arise by retrotransposition or duplication followed by mutational inactivation[2], and processed pseudogenes typically lack regulatory sequences and introns, precluding their normal expression. RNA5SP45 itself is not a therapeutic target (i.e., enzyme, receptor, or transporter) and has no known direct role in disease, clinical biomarker utility, or drug interaction. As with other pseudogenes, it may retain sequence similarity to its parental gene but is considered a genomic relic with negligible functional impact in human biology[2].\n\nKey details and justifications:\n- Not a therapeutic target: Pseudogenes in general, and processed ribosomal pseudogenes specifically, are not recognized as therapeutic targets in drug discovery or clinical application[2].\n- Incorrect as target: The entry "RNA, 5S ribosomal pseudogene 45" is not a correct drug target; it refers to a nonfunctional genomic locus, not a ribosomal RNA or protein impacting cell biology[2].\n- No drugs, MOA, biomarkers, or safety concerns: No drugs or mechanisms of action relate to this locus, and it is not used as a biomarker or associated with safety issues in therapeutics.\n\nNote:\nIf the intention was to identify the functional ribosomal RNA gene or its protein products, the correct target would be “5S ribosomal RNA,” not a pseudogene. Pseudogene entries such as RNA5SP45, by convention, should not be included as canonical drug targets or actionable biological entities[2].

Other names

RN5S45RNA, 5S ribosomal 45RNA5SP45