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RN7SKP49 is a human pseudogene derived from the 7SK small nuclear RNA locus. It is annotated due to sequence similarity but is generally transcriptionally inactive and does not produce a stable, functional RNA[3]. By sequence, it is related to RN7SK, which is a highly abundant noncoding RNA of ~330 nt transcribed by RNA polymerase III. RN7SK acts as a scaffold for the 7SK small nuclear ribonucleoprotein complex, recruiting factors such as HEXIM1/2 to regulate the positive transcription elongation factor b (P-TEFb) and control RNA polymerase II elongation, impacting cell growth, proliferation, differentiation, and responses to environmental stimuli[1][2][3].
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