RNA, 7SL, cytoplasmic 105, pseudogene (RN7SL105P)

**RN7SL105P** is a human pseudogene related to the 7SL RNA gene, which encodes the RNA component of the signal recognition particle (SRP)[1][7]. Most 7SL-related sequences in the human genome are pseudogenes resulting from the reverse flow of genetic information from 7SL RNA back into genomic DNA[1][7]. These pseudogenes are truncated, generally do not produce functional RNA, and are not thought to have physiological functions or disease roles. While the canonical 7SL RNA (e.g. RN7SL1) is essential for protein targeting to the endoplasmic reticulum as part of SRP, pseudogenes like RN7SL105P are generally transcriptionally inactive and considered genomic relics[1][7]. There is no evidence that RN7SL105P is a therapeutic target, a biomarker, or interacts with drugs. **Detailed justification:** - The designation "pseudogene" indicates **RN7SL105P is not a protein-coding gene, receptor, enzyme, or any classical therapeutic target**[2][7]. It is a truncated, non-functional derivative of the canonical 7SL RNA locus. - While parent 7SL RNA is part of a key ribonucleoprotein complex (SRP) with essential cellular functions, **the vast majority of 7SL pseudogenes (including RN7SL105P) do not encode products with known functional roles**[1][7]. - There are no reported disease associations, interacting drugs, or biomarker usage for this locus in current databases or biomedical literature[2][4]. - The name as provided is structurally correct and matches standard nomenclature for pseudogenes, but this "target" is not a real biological or therapeutic target and is therefore "incorrect" as a search target in those contexts[1][2][7]. - RN7SL105P may sometimes be included in transcriptome data or large-scale screens, but its annotation as a pseudogene means observed expression is likely artifactual or nonfunctional. **Summary:** RN7SL105P is a non-functional pseudogene derived from the 7SL RNA family, with no known biological or therapeutic relevance[1][2][7]. It should not be considered a drug target, biomarker, or disease gene.

Other names

RN7SL105P7SL RNA pseudogene7SL RNA-like pseudogene