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RNA, 7SL, cytoplasmic 118, pseudogene (RN7SL118P) is a human gene classified as a pseudogene, specifically one of the many pseudogenes derived from the 7SL RNA gene. 7SL RNA itself is a functional component of the signal recognition particle (SRP), a ribonucleoprotein complex involved in the targeting of proteins to the endoplasmic reticulum[1][3][7]. However, RN7SL118P represents a non-functional, non-coding copy (pseudogene) that arose through reverse transcription and reintegration of 7SL RNA sequences into genomic DNA[7]. As with other 7SL RNA pseudogenes, RN7SL118P is generally not transcribed into a functional RNA product, and there is no evidence suggesting it serves a biological function or that it acts as a therapeutic target[5][6][7]. Pseudogenes like RN7SL118P are not associated with disease roles, drug interactions, or biomarker utility, and are not considered druggable or therapeutic targets. Key context and supporting details: - RN7SL118P appears in gene databases as a pseudogene and is not listed with any synonyms or associated functional annotations[5][6]. - The majority of 7SL-derived loci in the human genome are pseudogenes, not the functional 7SL RNA genes; they do not encode functional RNA or protein products and are not involved in cellular signaling, enzymatic activity, transport, transcription, or other actionable biological roles[7]. - Pseudogenes may occasionally influence gene expression by "decoy" effects (e.g., as sources of small interfering RNA), but there is no data supporting this for RN7SL118P specifically[2].
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