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Target intelligence / Profile preview
RNA, 7SL, cytoplasmic 43, pseudogene (RN7SL43P)
- Target
- RN7SL43P
- Molecular classification
- Pseudogene (specifically, a non-coding RNA pseudogene), Homologous to signal recognition particle RNA (SRP RNA family)
01
Overview
RNA, 7SL, cytoplasmic 43, pseudogene (RN7SL43P) is an annotated pseudogene in the human genome related by sequence similarity to the functional 7SL RNA, a critical non-coding RNA component of the signal recognition particle (SRP). Pseudogenes like RN7SL43P result from ancient duplication or retrotransposition events and are defined by their incapacity to produce a functional product, as outlined in HGNC guidelines[4][6]. While the functional 7SL RNA has significant roles in protein targeting, translation regulation, and cancer biology, RN7SL43P itself does not possess biological activity, and there is no evidence supporting its role as a disease driver, drug target, or biomarker[2][4][6].
- Other names
- RN7SL43PRNA, 7SL, cytoplasmic 43, pseudogeneAlso related by homology to: 7SL RNA, SRP RNA, RNA, 7SL, cytoplasmic 1 (RN7SL1)
02
Mechanism of action
Not applicable; no drugs target RN7SL43P[2][4]
03
Biological functions
None known for RN7SL43P directly; it does not produce a functional product[2][4][6]The functional ancestor (7SL RNA) plays roles in SRP complex assembly, protein targeting to the endoplasmic reticulum, regulation of translation, and modulating p53 signaling in cancer[1][3][5]
04
Disease associations
None known for RN7SL43PThe functional ancestor (7SL RNA, RN7SL1) is upregulated in cancers and implicated in modulation of tumor suppressors such as p53[1][3]
05
Safety considerations
None documented for RN7SL43P.Pseudogenes in general do not express functional products and thus are not typically associated with adverse safety profiles[4][6]
06
Interacting drugs
None known for RN7SL43P. No drugs are documented to interact with this pseudogene[2][4][6]
07
Biomarkers
Not applicable for RN7SL43PFunctional 7SL RNA (not the pseudogene) has been explored as a biomarker in cancer[1][3]
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