RNA, 7SL, cytoplasmic 727, pseudogene (RN7SL727P)

RN7SL727P is a pseudogene related to the 7SL RNA, which constitutes the RNA core of the signal recognition particle (SRP) complex[1][3][5]. The functional 7SL RNA guides protein export and membrane targeting by binding ribosomes, stalling translation, and delivering proteins to translocation pores[3][5]. RN7SL727P, however, is a **truncated, nonfunctional copy** of the 7SL RNA gene, integrated into the genome presumably via reverse transcription, and does not encode a functional RNA component[7]. While a large number of 7SL-related pseudogenes are distributed across the human genome, only a few code for the functional SRP RNA; the vast majority, including RN7SL727P, are evolutionary remnants without known direct biological activity[7]. There are rare exceptions where other pseudogenes play epigenetic regulatory or miRNA-decoy roles, but no such function is established for RN7SL727P[2][4].

Other names

RN7SL727PRNA, 7SL, cytoplasmic pseudogene 727