RNA, U1 small nuclear 138, pseudogene (RNU1-138P)

"RNA, U1 small nuclear 138, pseudogene" (RNU1-138P) denotes a pseudogene copy of the gene encoding U1 small nuclear RNA, an essential component of the spliceosome complex. **Pseudogenes** are DNA sequences similar to known genes but are typically nonfunctional—they do not produce functional RNA or protein products and are not generally involved in standard biological processes, cellular signaling, or disease mechanisms. The canonical, functional U1 small nuclear RNA is crucial for 5′ splice site recognition in pre-mRNA splicing and maintaining transcriptome integrity, but RNU1-138P—as a pseudogene—is not known to have any coding or regulatory role[1][2][3]. As such, it is not considered a therapeutic target, has no known drug interactions, disease associations, biomarker utility, or safety concerns. The listing of this entity as a therapeutic or molecular target is likely **incorrect**. **Additional context:** - Functional U1 snRNA (not the pseudogene) is deeply involved in RNA splicing, transcript surveillance, and cellular differentiation, with indirect disease relevance, particularly in cancer and genetic disorders, but none of those roles are attributable to pseudogene copies like RNU1-138P[2][1][3]. - The presence of many pseudogenes for U1 snRNA in the genome is common, but these usually do not encode active RNA molecules or function in molecular complexes. **Summary of issues:** - RNU1-138P is a **pseudogene**, not a functional gene, protein, or recognized drug target. - It should not be listed as a therapeutic target.

Other names

RNU1-138PU1 small nuclear RNA pseudogene 138RNA, U1 snRNA 138, pseudogene